The Corporate Sustainability Due Diligence Directive proposal adopted by the European Commission on 23 February 2022 lays down rules for companies to respect human rights and the environment in global value chains. In this letter, co-signed by AK EUROPA, the undersigned organizations, welcome this long-awaited proposal. However, despite its groundbreaking potential, the Commission’s proposal is gender-blind and risks leaving women and girls behind. The current text does not recognize the fact that business and human rights abuses have differentiated impacts on individuals and groups in marginalized situations, including on women and girls. As the proposal makes its way through the European Parliament and the Council of the European Union, the undesigned organizations, AK EUROPA amongst, call on policy-makers to bring improvements to the proposal to ensure it is gender-responsive.